mashable recently posted two great articles, exploring the imperfections of Google and Facebook. To be fair, there's much more to the stories than that, but together, they serve to remind readers that while such massive companies have already created products that essentially serve a majority of users (well, this is certainly true in North America), they are not perfect. There's a number of ways that one can still get an edge on them.
Inpsiring? Certainly -- startups, have a chance! And what a complement to Inspiration #5!